GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6879260 | 1 | rs6874653 | chr5:179730843 | MAPK9 | chr5:179660597-179719071:- | 0.15 | 3.88 | 0.000119 | Height |
| THCA | cis | rs7714584 | 1 | rs6875011 | chr5:150182710 | LOC134466 | chr5:150310000-150326146:- | 0.44 | 5.78 | 1.35E-8 | Crohn's disease |
| THCA | cis | rs7714584 | 1 | rs6875011 | chr5:150182710 | ZNF300 | chr5:150273964-150284391:- | 0.19 | 3.87 | 0.000123 | Crohn's disease |
| THCA | cis | rs515910 | 1 | rs687557 | chr10:105989509 | C10orf79 | chr10:105889647-105992120:- | 0.24 | 7.79 | 4.15E-14 | Attention deficit hyperactivity disorder |
| THCA | cis | rs301901 | 1 | rs6875748 | chr5:37041593 | C5orf42 | chr5:37106330-37249530:- | 0.09 | 3.53 | 0.000452 | Height |
| THCA | cis | rs568617 | 1 | rs687672 | chr11:65649984 | CTSW | chr11:65647284-65651212:+ | 0.6 | 16.12 | 5.46E-47 | Crohn's disease |
| THCA | cis | rs568617 | 1 | rs687672 | chr11:65649984 | SNX32 | chr11:65601410-65621170:+ | -0.62 | -9.33 | 3.97E-19 | Crohn's disease |
| THCA | cis | rs10043228 | 1 | rs6876972 | chr5:115642519 | COMMD10 | chr5:115420727-115628978:+ | 0.4 | 4.86 | 1.58E-6 | Asthma or chronic obstructive pulmonary disease |
| THCA | cis | rs6878284 | 1 | rs6877722 | chr5:101709936 | SLCO4C1 | chr5:101569694-101632253:- | 0.25 | 5.81 | 1.13E-8 | Schizophrenia |
| THCA | cis | rs6878284 | 1 | rs6878284 | chr5:101769726 | SLCO4C1 | chr5:101569694-101632253:- | 0.24 | 5.45 | 8.22E-8 | Schizophrenia |
| THCA | cis | rs6878284 | 1 | rs6878326 | chr5:101757265 | SLCO4C1 | chr5:101569694-101632253:- | 0.24 | 5.52 | 5.5E-8 | Schizophrenia |
| THCA | cis | rs6879260 | 1 | rs6879260 | chr5:179731014 | MAPK9 | chr5:179660597-179719071:- | 0.16 | 4.02 | 6.68E-5 | Height |
| THCA | cis | rs10043228 | 1 | rs6880213 | chr5:115447414 | COMMD10 | chr5:115420727-115628978:+ | 0.5 | 6.16 | 1.54E-9 | Asthma or chronic obstructive pulmonary disease |
| THCA | cis | rs13174348 | 1 | rs6880889 | chr5:115167896 | ATG12 | chr5:115165818-115177520:- | -0.27 | -5.77 | 1.41E-8 | IgG glycosylation |
| THCA | cis | rs13174348 | 1 | rs6880889 | chr5:115167896 | CCDC112 | chr5:114602885-114632458:- | -0.17 | -3.54 | 0.000445 | IgG glycosylation |